Premature coronary artery disease risk in the Indian population is determined by genetic interactions between the MTHFR (C677T), methionine synthase (A2756G, C2758G) and vitamin B12 and folic acid variations.

V. V. Kanth , Jaya Prakash , Sudhir Naik

» doi: https://jcdponline.org/.2019.v10.i02.pp01-09

Abstract

For context, studies have shown that Indians had a greater risk of cardiovascular disease than the general population, even though many of the usual risk factors are absent among this population and about half of Indians eat only vegetarianism. Compared to whites in the UK and Chinese in Singapore, the coronary artery disease death rate among Indians in the under-30 age range is three times greater. Although there is a lack of conclusive evidence linking high homocysteine levels to the early beginning of cardiac problems in Indians, this has to be addressed by screening for the variables that cause these levels. The goal of this screening is to identify potential hereditary risk factors for hyperhomocysteinemia and early-onset coronary artery disease. Procedures and Materials: Polymorphisms in the Methylenetetrahydrofolate reductase (MTHFR) (C677T) and Methionine synthase (MS) genes (A2756G, C2758G) were tested in 100 people with confirmed early coronary artery diseas