Experimental investigation of cetirizine's antiinflammatory effects in albino r

Dipti R. Sonawane , B. Jaju , R. Pawar

» doi: https://jcdponline.org/.2016.v07.i02.pp01-12

Abstract

The several ways in which cetirizine inhibits inflammatory mediators, including histamine release, LTB4, Macrophage migratory inhibitory factor, kinin, and interleukin, suggest that it may have anti-inflammatory effects. We want to find out if cetirizine really does stop inflammation in its tracks by blocking inflammatory processes including the growth of inflammatory cells. Methods: We employed four sets of six albino Wistar rats, ranging in weight from 150 to 250 grams. In the first group, participants took 1% gum acacia or 2 milliliters per kilogram as a control. In the second group, participants took 4.5 milligrams per kilogram as the standard medication. In the third group, participants took 900 milligrams per kilogram of cetirizine dihydrochloride as the test drug. In the fourth group, participants took 900 milligrams of cetirizine dihydrochloride in addition to 4.5 milligrams of diclofenac sodium inside the test drugs. The medications were taken by mouth. T